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To determine the significance of differences between clonal libraries of environmental rRNA gene sequences, differences between homologous coverage curves, CX(D), and heterologous coverage curves, CXY(D), were calculated by a Cramér-von Mises-type statistic and compared by a Monte Carlo test procedure. This method successfully distinguished rRNA gene sequence libraries from soil and bioreactors and correctly failed to find differences between libraries of the same composition.
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Singleton et al. (Sat,) studied this question.
www.synapsesocial.com/papers/6a09020a2757fd3263d3a151 — DOI: https://doi.org/10.1128/aem.67.9.4374-4376.2001
David R. Singleton
Michelle Furlong
Stephen L. Rathbun
Applied and Environmental Microbiology
University of Georgia
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