Among hospitalized Medicare beneficiaries with cardiovascular disease, the presence of chronic kidney disease was associated with a significantly increased risk of progression to ESRD (OR 34.5; 95% CI 4.23-279.43 for CHF patients).
Cohort (n=1,157)
Effect estimate: OR 34.5 (95% CI 4.23-279.43)
The risk of progression to ESRD among individuals with cardiovascular disease and chronic kidney disease (CKD) is not well defined. The purpose of this study was to describe the risk of ESRD among patients with cardiovascular disease. Charts were abstracted for randomly selected hospitalized Medicare beneficiaries with a diagnosis of either congestive heart failure (CHF) or acute myocardial infarction (AMI). The prevalence of CKD, based on the estimated modified diet in renal disease GFR of <60 ml/min per m2, was 60.4% of CHF patients and 51.7% of AMI patients. When compared with patients without CKD, the 30-d readmission rate was higher for CHF patients with CKD (odds ratio OR, 1.70; 95% confidence interval CI, 1.18 to 2.44) and for AMI patients with CKD (OR, 1.78; 95% CI, 1.17 to 2.70). CHF patients (OR, 1.62; 95% CI, 1.15 to 2.30) and AMI patients (OR, 3.10; 95% CI, 1.98 to 4.84) with CKD were more likely to die during the year after discharge from the hospital. ESRD after discharge occurred in nine of 517 patients with AMI and 24 of 640 patients with CHF. CKD increased the risk of ESRD among CHF patients (OR, 34.5; 95% CI, 4.23 to 279.43) and AMI patients (0 and 3% for those without and with CKD, respectively). At discharge, 18% of AMI patients and 21% of CHF patients with CKD were discharged with a diagnosis of renal disease. CKD is highly prevalent among patients with cardiovascular disease and is associated with increased risk of adverse outcomes, including progression to ESRD. This study suggests that opportunities may exist to improve the detection of CKD in these patients who are hospitalized with cardiovascular disease.
McClellan et al. (Thu,) conducted a cohort in Cardiovascular disease (CHF or AMI) and Chronic Kidney Disease (n=1,157). Chronic Kidney Disease (CKD) vs. No CKD was evaluated on End-stage renal disease (ESRD) after discharge among CHF patients (OR 34.5, 95% CI 4.23-279.43). Among hospitalized Medicare beneficiaries with cardiovascular disease, the presence of chronic kidney disease was associated with a significantly increased risk of progression to ESRD (OR 34.5; 95% CI 4.23-279.43 for CHF patients).