Native T1 mapping at 3 T yielded significantly longer relaxation times in acute myocarditis patients versus controls (1185.3 vs 1089.1 msec; P<0.001) and provided high diagnostic accuracy (AUC 0.94).
Case-Control (n=66)
Effect estimate: AUC 0.94
Absolute Event Rate: 1185.3% vs 1089.1%
p-value: p=<0.001
PURPOSE: To evaluate the diagnostic value of cardiac magnetic resonance (MR) imaging at 3 T in patients suspected of having acute myocarditis by using a multiparametric cardiac MR imaging approach including T1 relaxation time as an additional tool for tissue characterization. MATERIALS AND METHODS: Ethics commission approval was obtained for this prospective study, and written informed consent was obtained from all subjects. Twenty four patients with acute myocarditis (mean age ± standard deviation, 34.7 years ± 15.1; 75% men) and 42 control subjects (mean age, 38.7 years ± 10.2; 64% men) were included. Cardiac MR imaging approaches included relative T2 short tau inversion-recovery signal intensity ratio (T2 ratio), early gadolinium enhancement ratio, late gadolinium enhancement, native T1 relaxation times, and extracellular volume fraction. Receiver operating characteristic analysis was performed to compare diagnostic performance. The reference standard was the clinical evidence for acute myocarditis. RESULTS: Native T1 relaxation times were significantly longer in patients with acute myocarditis than in control subjects (1185.3 msec ± 49.3 vs 1089.1 msec ± 44.9, respectively; P < .001). Areas under the curve of native T1 relaxation times (0.94) were higher compared with those of other cardiac MR parameters (late gadolinium enhancement, 0.90; T2 ratio, 0.79; extracellular volume fraction, 0.71; early gadolinium enhancement ratio, 0.63; P = .390, .018, .002, and < .001, respectively). Sensitivity (92%), specificity (91%), and diagnostic accuracy (91%) for native T1 relaxation times (cutoff, 1140 msec) were equivalent compared with those of the established combined Lake Louise criteria (sensitivity, 92%; specificity, 80%; diagnostic accuracy, 85%). CONCLUSION: Diagnostic performance with native T1 mapping was superior to that with T2 ratio and early gadolinium enhancement ratio, and specificity was higher with native T1 mapping than that with Lake Louise criteria. This study underlines the potential of native T1 relaxation times to complement current cardiac MR approaches in patients suspected of having acute myocarditis.
Luetkens et al. (Mon,) conducted a case-control in Acute myocarditis (n=66). Multiparametric cardiac MR imaging at 3 T (native T1 mapping) vs. Control subjects and established Lake Louise criteria was evaluated on Native T1 relaxation times (AUC 0.94, p=<0.001). Native T1 mapping at 3 T yielded significantly longer relaxation times in acute myocarditis patients versus controls (1185.3 vs 1089.1 msec; P<0.001) and provided high diagnostic accuracy (AUC 0.94).