Newly detected abnormal glucose tolerance in patients with acute myocardial infarction was associated with an increased risk of cardiovascular events over a decade (HR 2.30; 95% CI 1.24-4.25; p=0.008).
Cohort (n=351)
Does newly detected abnormal glucose tolerance worsen long-term cardiovascular outcomes in patients with acute myocardial infarction?
Newly detected abnormal glucose tolerance following an acute myocardial infarction is a strong, independent predictor of long-term cardiovascular events and mortality.
Effect estimate: HR 2.30 (95% CI 1.24-4.25)
p-value: p=0.008
OBJECTIVE: To investigate long-term prognostic importance of newly discovered glucose disturbances in patients with acute myocardial infarction (AMI). METHODS: During 1998-2001, consecutive patients with AMI (n = 167) and healthy controls (n = 184) with no previously known diabetes were investigated with an oral glucose tolerance test (OGTT). Patients and controls were separately followed up for cardiovascular events (first of cardiovascular mortality/AMI/stroke/heart failure) during a decade. RESULTS: In all, 68% of the patients and 35% of the controls had newly detected abnormal glucose tolerance (AGT). Cardiovascular event (n = 72, p = 0.0019) and cardiovascular mortality (n = 31, p = 0.031) were more frequent in patients with newly detected AGT. Regarding patients, a Cox proportional-hazard regression analysis identified AGT (hazard ratio (HR): 2.30; 95% confidence interval (CI): 1.24-4.25; p = 0.008) and previous AMI (HR: 2.39; CI: 1.31-4.35; p = 0.004) as prognostically important. CONCLUSION: An OGTT at discharge after AMI disclosed a high proportion of patients with previously unknown AGT which had a significant and independent association with long-term prognosis.
Ritsinger et al. (Mon,) conducted a cohort in Acute myocardial infarction (n=351). Newly detected abnormal glucose tolerance vs. Normal glucose tolerance was evaluated on Cardiovascular events (first of cardiovascular mortality/AMI/stroke/heart failure) (HR 2.30, 95% CI 1.24-4.25, p=0.008). Newly detected abnormal glucose tolerance in patients with acute myocardial infarction was associated with an increased risk of cardiovascular events over a decade (HR 2.30; 95% CI 1.24-4.25; p=0.008).