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The combination of 18 to 69 hours of complete diaphragmatic inactivity and mechanical ventilation results in marked atrophy of human diaphragm myofibers. These findings are consistent with increased diaphragmatic proteolysis during inactivity.
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Sanford Levine
University of Pennsylvania
Taitan Nguyen
University of Pennsylvania
Nyali Taylor
Einstein Medical Center Philadelphia
New England Journal of Medicine
University of Pennsylvania
University of Florida
Gift of Life Michigan
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Levine et al. (Wed,) studied this question.
synapsesocial.com/papers/69d98e441ad561c67368493b — DOI: https://doi.org/10.1056/nejmoa070447