In silico modeling showed that aortic wall inclusions did not significantly affect pulse velocity beyond the inclusion site, suggesting global average PWV may fail to detect regional abnormalities.
Can regional pulse wave propagation detect aortic wall inclusions better than global average PWV in silico?
In silico modeling demonstrates that regional pulse wave analysis is necessary to detect aortic wall inclusions, as global PWV measurements miss these localized abnormalities.
= 0.9988), indicating the reliability of the model to accurately represent the wave propagation. On the inhomogeneous aortas, formation of reflected and standing waves was observed at the site of the hard and soft inclusions, respectively. Neither the hard nor the soft inclusion had a significant effect on the velocity of the traveling pulse beyond the inclusion site, which supported the hypothesis that a global measurement of the average PWV could fail to detect regional abnormalities.
Shahmirzadi et al. (Sun,) conducted a other in Aortic wall inclusions. Regional pulse wave propagation and velocity vs. Global measurement of average PWV was evaluated on Effect of inclusions on velocity of traveling pulse. In silico modeling showed that aortic wall inclusions did not significantly affect pulse velocity beyond the inclusion site, suggesting global average PWV may fail to detect regional abnormalities.