Oral administration of murine-adapted strains of poliomyelitis virus resulted in paralytic poliomyelitis in 2 of 7 infant rhesus monkeys.
Although rhesus monkeys have been generally regarded as refractory to infection with poliomyelitis virus administered by the oral route, two of seven infant rhesus developed paralytic poliomyelitis when fed murine-adapted strains of virus. Preliminary intranasal treatment with zinc sulfate and negative serial sections of the olfactory bulbs of the positive animals ruled out the possibility that infection occurred by way of the olfactory pathway. Studies on the distribution of virus in the tissues of the infected animals yielded positive results in one animal only. In this instance, virus was widely distributed throughout the body being isolated from spinal cord, buccal mucosa, duodenal wall, colon contents, superficial lymph nodes, spleen, heart, and adrenals.
Horstmann et al. (1947) studied Poliomyelitis (n=7). Oral administration of murine-adapted strains of poliomyelitis virus was evaluated on Development of paralytic poliomyelitis. Oral administration of murine-adapted strains of poliomyelitis virus resulted in paralytic poliomyelitis in 2 of 7 infant rhesus monkeys.