Right ventricular pacing can induce dyssynchronous activation, worsen cardiac output, and cause pacing-induced cardiovascular disease, highlighting the need for strategies to mitigate these effects.
Pacemaker implantation remains the only therapeutic option that improves morbidity and mortality for patients with symptomatic bradycardia. However, pacing from the right ventricular apex can induce dyssynchronous activation of the ventricles, increase sympathetic activation, cause abnormalities in myocardial perfusion, worsen cardiac output and endothelial function and may be associated with adverse cardiovascular outcomes. This article reviews the current knowledge on the pathophysiology of pacing-induced cardiovascular disease and current strategies to avoid and mitigate the adverse effects of right ventricular pacing.
Elder et al. (Fri,) conducted a review in Symptomatic bradycardia and pacing-induced heart disease. Right ventricular pacing was evaluated. Right ventricular pacing can induce dyssynchronous activation, worsen cardiac output, and cause pacing-induced cardiovascular disease, highlighting the need for strategies to mitigate these effects.
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