Does β-Blocker therapy prevent cAMP-dependent upregulation of MMP expression and activity and disorganization of the N-cadherin/β-catenin cell adhesion complex in PI3KγKO mice?
β-Blocker therapy prevents cAMP-dependent MMP remodeling and cell adhesion complex disorganization in PI3KγKO mice, revealing a novel mechanism of action for these drugs in heart failure.
The enhanced propensity to develop heart failure in the PI3KγKO mice is attributable to a cAMP-dependent upregulation of MMP expression and activity and disorganization of the N-cadherin/β-catenin cell adhesion complex. β-Blocker therapy prevents these changes thereby providing a novel mechanism of action for these drugs.
Guo et al. (Fri,) studied this question.
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