July 29, 2005Open Access
View Full PaperElevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
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Abstract
Myocardial GRK2 expression and activity are mirrored by lymphocyte levels of this kinase, and its elevation in HF is associated with the loss of beta-AR responsiveness and appears to increase with disease severity. Therefore, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.