Radiotherapy for breast cancer increases the risk of ischemic heart disease in women, proportional to heart radiation dose, lasting for over 20 years.
Does incidental radiation exposure to the heart increase the risk of major coronary events in women undergoing radiotherapy for breast cancer?
Women who underwent external-beam radiotherapy for invasive breast cancer between 1958 and 2001
Higher mean radiation dose to the heart
Lower or no radiation exposure to the heart
Major coronary events (myocardial infarction, coronary revascularization, or death from ischemic heart disease)hard clinical
Incidental radiation exposure to the heart during breast cancer radiotherapy linearly increases the long-term risk of major coronary events by 7.4% per gray, with no apparent safe threshold.
Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease. The increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years. Women with preexisting cardiac risk factors have greater absolute increases in risk from radiotherapy than other women. (Funded by Cancer Research UK and others.).
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Sarah C. Darby
Marianne Ewertz
Paul McGale
New England Journal of Medicine
University of Oxford
Karolinska Institutet
Karolinska University Hospital
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Darby et al. (Wed,) reported a other. Radiotherapy for breast cancer increases the risk of ischemic heart disease in women, proportional to heart radiation dose, lasting for over 20 years.
www.synapsesocial.com/papers/69696f2d89bff51f66b067fe — DOI: https://doi.org/10.1056/nejmoa1209825