In a nationwide Italian registry of acute heart failure, in-hospital mortality was 7.3%, with a 6-month rehospitalization rate of 38.1% and 6-month post-discharge mortality of 12.8%.
Observational (n=2,807)
Yes
AIMS: Chronic heart failure (HF) is recognized as an important public health problem but little attention has been focused on acute-stage HF. METHODS AND RESULTS: Nationwide, prospective, observational study setting 206 cardiology centres with intensive cardiac care units. During 3 months, 2807 patients diagnosed as having de novo acute HF (44%) or worsening chronic HF (56%) were enrolled. Acute pulmonary oedema was the presenting clinical feature in 49.6% of patients, cardiogenic shock in 7.7%, and worsened NYHA functional class in 42.7% of cases. Anaemia (Hb or =1.5 mg%) in 47%, and hyponatraemia (40% was found in 34% of cases. Intravenous diuretics, nitrates, and inotropes were given to 95, 51, and 25% of patients, respectively. The median duration of hospital stay was 9 days. In-hospital mortality rate was 7.3%. Older age, use of inotropic drugs, elevated troponin, hyponatraemia, anaemia, and elevated blood urea nitrogen were independent predictors of all-cause death; prior revascularization procedures and elevated blood pressure were indicators of a better outcome. The rehospitalization rate within 6 months was 38.1%, all-cause mortality from discharge to 6 months was 12.8%. CONCLUSION: Acute HF is an ominous condition, needing more research activity and resources.
Luigi Tavazzi (Mon,) conducted a observational in Acute heart failure (n=2,807). In a nationwide Italian registry of acute heart failure, in-hospital mortality was 7.3%, with a 6-month rehospitalization rate of 38.1% and 6-month post-discharge mortality of 12.8%.
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