Does losartan reduce myocardial fibrosis and left ventricular chamber stiffness in patients with essential hypertension?
Losartan may improve left ventricular chamber stiffness by regressing myocardial fibrosis in patients with essential hypertension.
These findings show a strong association between myocardial collagen content and LV chamber stiffness in patients with essential hypertension. Our results also suggest that the ability of losartan to induce regression of severe myocardial fibrosis is associated with diminution of myocardial stiffness in hypertensive patients.
Dı́ez et al. (Tue,) studied this question.