Clathrin, Adaptors, and Sorting

CONTENTS INTRODUCTION 15 1 COAT COMPONENTS 153 Clathrin Triskelions and Adaptors ....... 153 Function and Distribution of Adaptors 156 COATED PITS AS MOLECULAR FILTERS ......... ... .. 159 Clathrin-Mediated Endocytosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 Clathrin-Mediated Intracellular Sorting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 62 Defective Sorting in Yeast Cells Lacking Clathrin ... 165 Interaction of Receptors with Adaptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 CONCLUSIONS AND PROBLEMS 167