PTCA significantly increased regional myocardial peak systolic velocity (5.8 vs 7.7 cm/s) and velocity time integral (1.06 vs 1.23 cm) in ischaemic segments of patients with >70% stenosis (P<0.03).
Observational (n=30)
Does PTCA improve regional myocardial function assessed by Doppler myocardial imaging in patients with single vessel disease?
Doppler myocardial imaging can quantify improvements in regional myocardial function following successful PTCA in patients with significant coronary stenosis.
Absolute Event Rate: 7.7% vs 5.8%
p-value: p=< 0.03
AIMS: Doppler myocardial imaging is potentially a sensitive tool to assess regional myocardial velocities pre- and post-percutaneous transluminal coronary angioplasty (PTCA) as a marker of contractility to evaluate short- to medium-term information on functional myocardial recovery following the release of ischaemia. METHODS: Thirty patients with single vessel disease were studied to assess regional myocardial peak systolic velocity, systolic velocity time integral and mitral valve plane excursion in longitudinal direction one day pre-, one day post- and 3 months post-PTCA. The patients were assigned to group A with coronary stenoses >70% and group B with stenoses < 70%. RESULTS: In group A pre-PTCA the ischaemic segments showed a significantly lower peak systolic velocity and velocity time integral compared with the values one day after PTCA (5.8 +/- 1.4 vs 7.7 +/- 1.4cm.s(-1); 1.06 +/- 0.22 vs 1.23 +/-0.28cm;P< 0.03). In contrast, mitral valve plane excursion in this group remained unchanged after PTCA for both the ischaemic and non-ischaemic left ventricular wall. In group B no changes of these parameters and no differences in mitral valve plane excursion of the ischaemic and the non-ischaemic left ventricular wall could be seen. CONCLUSION: With Doppler myocardial imaging it was possible to quantify a number of indices which changed due to the successful release of ischaemia.
Johanna Strotmann (Sat,) conducted a observational in Single vessel disease (n=30). PTCA vs. Pre-PTCA baseline was evaluated on Regional myocardial peak systolic velocity (p=< 0.03). PTCA significantly increased regional myocardial peak systolic velocity (5.8 vs 7.7 cm/s) and velocity time integral (1.06 vs 1.23 cm) in ischaemic segments of patients with >70% stenosis (P<0.03).