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Abstract When red blood cells or lymphocytes were fixed with glutaraldehyde, binding assays for determinants recognized by antibodies could be carried out in the presence of nonionic detergents. Specific inhibition of the binding assays by detergent‐solubilized membranes and cell extracts was possible, thus allowing rapid routine assays of detergent extracts during the purification of membrane components. The assay system was established for rat histocompatibility antigens and for cell‐associated immunoglobulin.
Abigail Williams (Mon,) studied this question.