February 18, 2004Open Access
View Full PaperTemplated Ligand Assembly by Using G‐Quadruplex DNA and Dynamic Covalent Chemistry
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Abstract
Reversible disulfide chemistry is used to identify ligands that bind G-quadruplex DNA from a small dynamic combinatorial library (DCL) (see scheme). The biological macromolecular target is shown to induce an equilibrium shift. Surface plasmon resonance demonstrates that the two amplified species bind the quadruplex DNA.