Is there a causal link between knee loading and knee osteoarthritis progression? A systematic review and meta-analysis of cohort studies and randomised trials

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables· 2011 · 10,388 citations
2. Unloading joints to treat osteoarthritis, including joint distraction· 2006 · 95 citations
3. Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee· 1986 · 6,769 citations
4. Increased joint loads during walking – A consequence of pain relief in knee osteoarthritis· 2006 · 119 citations
5. Effects of a modified shoe on knee load in people with and those without knee osteoarthritis· 2012 · 46 citations