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Most patients with essential thrombocythemia or primary myelofibrosis that was not associated with a JAK2 or MPL alteration carried a somatic mutation in CALR. The clinical course in these patients was more indolent than that in patients with the JAK2 V617F mutation. (Funded by the MPN Research Foundation and Associazione Italiana per la Ricerca sul Cancro.).
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Thorsten Klampfl
University of Veterinary Medicine Vienna
Heinz Gisslinger
Medical University of Vienna
Ashot S. Harutyunyan
Yerevan State University
New England Journal of Medicine
Istituti di Ricovero e Cura a Carattere Scientifico
Medical University of Vienna
University of Pavia
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Klampfl et al. (Tue,) studied this question.
synapsesocial.com/papers/69dada7c387cf70698687dcd — DOI: https://doi.org/10.1056/nejmoa1311347