Key points are not available for this paper at this time.
To clot or not to clot: The coagulation system is a multienzymatic network associated with bleeding or thrombosis in patients. A supramolecular oligonucleotide-adapted approach (see picture) makes thrombin, the key enzyme of this network, measurable in vivo. In patients undergoing hip-replacement surgery, thrombin was identified as a valuable biomarker to allow monitoring of the activity level of the coagulation system under clinical conditions.
Müller et al. (2011) studied this question.