Handgrip exercise training in healthy men prolonged time-to-peak brachial artery diameter at week 4 (77s vs baseline 42s, P<0.001), though responses returned to near baseline levels by week 8.
Does an 8-week handgrip exercise training regimen alter the diameter dilator response to forearm ischaemia in healthy young men?
Handgrip exercise training initially increases the magnitude and time-to-peak of flow-mediated dilation, but these vascular adaptations are transient and return to near baseline levels by 8 weeks.
Absolute Event Rate: 77% vs 42%
p-value: p=<0.001
AIM: Recent studies found differences between groups in the rate of diameter increase following the flow-mediated dilation (FMD). Whilst exercise training alters the magnitude of the FMD, little is known about the impact of exercise training on the rate of diameter increase. The aim of this study is to examine post-cuff deflation changes in brachial artery diameter following 5 min forearm ischaemia every 2 weeks across 8-weeks of a handgrip exercise training regimen. METHODS: Post-deflation changes in brachial artery diameter following 5-min of ischaemia were examined before, after and every 2-weeks across an 8-week handgrip training programme in healthy young men (n = 11) using echo-Doppler. RESULTS: The magnitude of dilation increased at week 2-4-6, but returned towards baseline values at week 8 (anova: P = 8.001). The time-to-peak diameter (42 ± 15s) demonstrated a significant prolongation at week 4 (77 ± 32s), but returned towards baseline values at weeks 6 and 8 (anova: P < 0.001). The rate of diameter increase did not differ across the intervention. CONCLUSION: Exercise training in healthy subjects is initially characterized by a larger dilation. Since the rate of dilation did not change, a longer time-to-peak dilation was necessary to achieve the increase in magnitude of dilation. As exercise training continues, the timing and magnitude of the peak diameter response returns to near baseline levels.
Thijssen et al. (Sat,) conducted a other in Healthy (n=11). Handgrip exercise training vs. Baseline was evaluated on Time-to-peak brachial artery diameter following 5-min forearm ischaemia (p=<0.001). Handgrip exercise training in healthy men prolonged time-to-peak brachial artery diameter at week 4 (77s vs baseline 42s, P<0.001), though responses returned to near baseline levels by week 8.