Does Compound 21 improve arterial baroreflex sensitivity and suppress sympathetic outflow in rats with heart failure?
Activation of central AT2R by Compound 21 improves baroreflex sensitivity and suppresses sympathetic outflow in a rat model of heart failure.
Activation of central angiotensin II type 2 receptor AT2R by C21 suppresses sympathetic outflow in rats with HF by improving baroreflex sensitivity and may provide important benefit in the HF syndrome.
Gao et al. (Mon,) studied this question.