Does BAF treatment during the subacute stage improve cardiac remodeling and dysfunction at the chronic stage after myocardial infarction?
Myocardial infarction model
BAF treatment during the subacute stage
Cardiac remodeling and dysfunction at the chronic stagesurrogate
Inhibition of granulation tissue cell apoptosis with BAF during the subacute stage of myocardial infarction improves chronic cardiac remodeling and dysfunction.
The postinfarct treatment with BAF improved LV remodeling and dysfunction through inhibition of granulation tissue cell apoptosis. These findings imply a new therapeutic strategy against postinfarct heart failure.
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Kenji Hayakawa
Novartis (Switzerland)
Genzou Takemura
Heart Failure / Cardiomyopathy
Motoo Kanoh
Gifu University
Circulation
Gifu University
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Hayakawa et al. (Tue,) studied this question.
synapsesocial.com/papers/69d575c8c928a9acfd89a22e — DOI: https://doi.org/10.1161/01.cir.0000074225.62168.68