Age, body weight, and heart rate significantly influenced Doppler-derived indices of left atrial and left ventricular filling, such as isovolumic relaxation time and deceleration time, in clinically normal dogs.
Observational (n=92)
Do age, body weight, heart rate, sex, and left ventricular shortening fraction influence transmitral and pulmonary venous flow in clinically normal dogs?
Age, body weight, and heart rate significantly affect Doppler-derived indices of left ventricular diastolic function in clinically normal dogs, highlighting the need to account for these physiologic variables when assessing diastolic dysfunction.
Effect estimate: r = 0.56
p-value: p=<0.05
OBJECTIVE: To determine the influence of age, body weight (BW), heart rate (HR), sex, and left ventricular shortening fraction (LVSF) on transmitral and pulmonary venous flow in clinically normal dogs. ANIMALS: 92 client-owned dogs 3 months to 19 years old. PROCEDURE: Transthoracic Doppler echocardiography recordings of transmitral flow and pulmonary venous flow were obtained in conscious unsedated dogs. Influence of age, BW, HR, sex, and LVSF on diastolic variables was assessed, using statistical methods such as ANOVA on ranks and univariate and multivariate forward stepwise linear regression analyses. RESULTS: Age significantly influenced isovolumic relaxation time (IVRT, r = 0.56), ratio between peak velocity of the early diastolic mitral flow wave-to-peak velocity of late diastolic mitral flow wave (E:A; r = -0.44), deceleration time of early diastolic mitral flow (DTE; r = 0.26), and peak velocity of atrial reversal pulmonary venous flow wave (AR-wave; r = 0.37). Significant changes of mitral inflow and pulmonary venous flow variables were evident only in dogs > 6 and > 10 years old, respectively. Body weight significantly influenced DTE (r = 0.63), late diastolic flow duration (r = 0.60), and AR duration (r = 0.47), whereas HR significantly affected DTE (r = -0.34), IVRT (r = -0.33), and peak velocity of AR (r = 0.24). Sex or LVSF (range 22 to 48%) did not influence any echocardiographic variables. CONCLUSIONS AND CLINICAL RELEVANCE: Age, BW, and HR are important factors that affect filling of the left atrium and left ventricle in clinically normal dogs.
Schober et al. (Sat,) conducted a observational in Clinically normal dogs (n=92). Age, body weight, and heart rate (Observational) was evaluated on Correlation between age and isovolumic relaxation time (IVRT) (r = 0.56, p=<0.05). Age, body weight, and heart rate significantly influenced Doppler-derived indices of left atrial and left ventricular filling, such as isovolumic relaxation time and deceleration time, in clinically normal dogs.