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Our experiments provide the first evidence for a peripheral blood protein signature in IPF to our knowledge. The two main components of this signature, MMP7 and MMP1, are overexpressed in the lung microenvironment and distinguish IPF from other chronic lung diseases. Additionally, increased MMP7 concentration may be indicative of asymptomatic ILD and reflect disease progression.
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Iván O. Rosas
Thomas J. Richards
Kazuhisa Konishi
PLoS Medicine
SHILAP Revista de lepidopterología
National Institutes of Health
University of Pittsburgh
National Heart Lung and Blood Institute
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Rosas et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d77f27b843b2be994900e9 — DOI: https://doi.org/10.1371/journal.pmed.0050093