Admission plasma MIF levels were elevated in 68% of STEMI patients and significantly correlated with CMR-derived infarct size, ventricular volumes, and ejection fraction (r=0.46 to 0.77, P<0.01).
Observational (n=374)
Does admission plasma macrophage migration inhibitory factor (MIF) level predict infarct size and cardiac remodeling in patients with STEMI?
Plasma MIF levels measured at admission in STEMI patients are predictive of final infarct size and the extent of cardiac remodeling.
Effect estimate: r = 0.46 to 0.77
p-value: p=< 0.01
BACKGROUND: Early diagnosis and knowledge of infarct size is critical for the management of acute myocardial infarction (MI). We evaluated whether early elevated plasma level of macrophage migration inhibitory factor (MIF) is useful for these purposes in patients with ST-elevation MI (STEMI). METHODS AND RESULTS: We first studied MIF level in plasma and the myocardium in mice and determined infarct size. MI for 15 or 60 minutes resulted in 2.5-fold increase over control values in plasma MIF levels while MIF content in the ischemic myocardium reduced by 50% and plasma MIF levels correlated with myocardium-at-risk and infarct size at both time-points (P 41.6 ng/mL), a proportion similar to hsTnI (75%) and TnI (50%), but greater than other biomarkers studied (20% to 31%, all P < 0.05 versus MIF). Only admission MIF levels correlated with CMR-derived infarct size, ventricular volumes and ejection fraction (n = 42, r = 0.46 to 0.77, all P < 0.01) at 3 day and 3 months post-MI. CONCLUSION: Plasma MIF levels are elevated in a high proportion of STEMI patients at the first obtainable sample and these levels are predictive of final infarct size and the extent of cardiac remodeling.
Chan et al. (Thu,) conducted a observational in ST-elevation myocardial infarction (STEMI) (n=374). Admission plasma macrophage migration inhibitory factor (MIF) levels vs. Healthy controls and other biomarkers was evaluated on Correlation with CMR-derived infarct size, ventricular volumes and ejection fraction (r = 0.46 to 0.77, p=< 0.01). Admission plasma MIF levels were elevated in 68% of STEMI patients and significantly correlated with CMR-derived infarct size, ventricular volumes, and ejection fraction (r=0.46 to 0.77, P<0.01).