Sixteen days of apixaban treatment resulted in complete resolution of a left atrial appendage thrombus in a 72-year-old male with persistent atrial fibrillation.
Case Report (n=1)
No
Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preventing stroke or systemic embolism, causes less bleeding, and results in lower mortality in patients with atrial fibrillation. There are few reports of resolution of LAA thrombus with other NOAC. We present a 72-year-old male patient with persistent atrial fibrillation associated with left atrial thrombus. Sixteen days of apixaban treatment showed complete thrombus resolution. In this study, soluble fibrin and D-dimer levels decreased without prolongation of international normalized ratio (INR) and activated partial thromboplastin time (APTT).
Kawakami et al. (Tue,) conducted a case report in Left atrial appendage thrombus and persistent atrial fibrillation (n=1). Apixaban was evaluated on Resolution of left atrial appendage thrombus. Sixteen days of apixaban treatment resulted in complete resolution of a left atrial appendage thrombus in a 72-year-old male with persistent atrial fibrillation.