Middle-site LAD occlusion in a swine model resulted in a significantly higher incidence of ventricular fibrillation compared to bottom-third LAD occlusion (100% vs 33.33%, P=0.012).
Does the site of LAD occlusion affect the development of AMI and malignant arrhythmia in a swine model?
In a swine model of AMI, middle-site LAD occlusion results in larger infarct sizes, worse hemodynamics, and a higher incidence of malignant arrhythmias compared to distal occlusion.
Absolute Event Rate: 100% vs 33.33%
p-value: p=0.012
OBJECTIVE: To explore the effects of various left anterior descending (LAD) artery-blocked sites on the development of acute myocardial infarction (AMI) and malignant arrhythmia in a swine model. METHODS: Twenty-two pigs underwent occlusion of the coronary artery with balloon angioplasty were randomly divided into three groups according to the blocked site of the balloon: middle-site-blocked LAD group, bottom-third-blocked LAD group and control group. Then, the development of AMI and malignant arrhythmia, including ventricular tachycardia and ventricular fibrillation during the process of model creation, were recorded. Changes of the hemodynamics, blood gas analysis, electrocardiography, and myocardial enzymes were analyzed in each group before and after occlusion. RESULTS: Middle-site-LAD blockage resulted in a larger infarction size and the corresponding incidence of ventricular fibrillation was significantly higher than that of the bottom-third-blocked group (P0.05). CONCLUSIONS: Location of LAD blockages in swine models may affect the development of AMI and malignant arrhythmia.
Li et al. (Mon,) conducted a other in Acute myocardial infarction and malignant arrhythmia (n=22). Middle-site LAD occlusion vs. Bottom-third LAD occlusion was evaluated on Incidence of ventricular fibrillation (p=0.012). Middle-site LAD occlusion in a swine model resulted in a significantly higher incidence of ventricular fibrillation compared to bottom-third LAD occlusion (100% vs 33.33%, P=0.012).