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DNA restriction and modification enzymes are responsible for the hostspecific barriers to interstrain and interspecies transfer of genetic information that have been observed in a variety of bacterial cell types. Although the phenomenon of host specificity was initially observed in the early 1950s (Luria Bertani Dussoix Arber, Hattman & Dussoix, 1963).
Paul Modrich (Wed,) studied this question.
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