Acute ischemia induced by coronary ligation caused a significant decrease in the angle of cardiac rotation (-37±6%) and maximum angular velocity (-21±4%) measured by epicardial gyroscopic sensors.
Can gyroscopic sensors accurately quantify cardiac rotation and detect LV twist alterations during acute ischemia in an animal model?
Gyroscopic sensors can feasibly assess cardiac rotation and detect LV twist alterations during acute ischemia in an animal model.
During the cardiac cycle, contraction of the helically oriented myocardial fibers results in torsion, a wringing motion as the cardiac apex rotates with respect to the base about the Left Ventricle (LV) long axis. We evaluated in animals the use of gyroscopic sensors to quantify cardiac rotation, which was demonstrated to be a sensitive index of cardiac function. Three gyroscopes were epicardially glued at different levels along the LV long axis (apex, middle, base) to assess LV twist dynamics: Angular Velocity (Ang V) and Angle of cardiac rotation (Angle) were measured and evaluated against hemodynamic measurements of LV pressure (LVP, LVdP/dt), at baseline and after acute ischemia induced by coronary ligation. Results demonstrated the feasibility of assessing cardiac rotation and LV twist alterations by means of gyroscopic sensors, especially at apical level: compared with baseline, acute ischemia caused a significant decrease of both Angle and the maximum value of Ang V (mean variation of −37±6% and −21±4%, respectively); a concomitant reduction of LVdP/dt MAX (−43±4%) was observed.
Marcelli et al. (Mon,) conducted a other in Acute ischemia. Acute ischemia induced by coronary ligation vs. Baseline was evaluated on Angle of cardiac rotation and maximum Angular Velocity. Acute ischemia induced by coronary ligation caused a significant decrease in the angle of cardiac rotation (-37±6%) and maximum angular velocity (-21±4%) measured by epicardial gyroscopic sensors.