September 4, 2014Open Access

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Key Points

Key points are not available for this paper at this time.

Abstract

In this study, we demonstrate that the mitochondrial enzyme SHMT2 is induced upon hypoxic stress and is critical for maintaining NADPH production and redox balance to support tumor cell survival and growth.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Jiangbin Ye

Jing Fan

Sriram Venneti

Journals

Cancer Discovery

Actions

Institutions

Howard Hughes Medical Institute

Princeton University

Memorial Sloan Kettering Cancer Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study