Arterial catecholamine concentrations during mental arithmetic explained 12.7% of the variation in future systolic blood pressure at 18-year follow-up (adjusted R2=0.651; P<0.001).
Cohort (n=99)
Does sympathoadrenal stress reactivity predict future blood pressure in healthy young men?
Sympathetic nervous activity during mental stress in healthy young men is an independent predictor of future blood pressure, suggesting a causal role in essential hypertension development.
Effect estimate: adjusted R(2)=0.651
p-value: p=<0.001
In the present study we hypothesized that arterial catecholamine concentrations during rest and 2 laboratory stress tests were independent predictors of blood pressure at an 18-year follow-up. At entry, blood pressure, heart rate, and arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men (age: 19.3+/-0.4 years, mean+/-SD) at rest, during a mental arithmetic test, and during a cold pressor test. After 18.0+/-0.9 years of follow-up, resting blood pressure was measured. The norepinephrine and epinephrine concentrations during the mental arithmetic explained 12.7% of the variation of future systolic blood pressure after adjusting for initial resting blood pressure, family history, body mass index, and systolic blood pressure during the stress test in a multiple regression analysis (adjusted R(2)=0.651; P<0.001). To conclude, the present study shows that sympathetic nervous activity during mental arithmetic predicts future blood pressure, indicating a possible causal factor in the development of essential hypertension independent of the initial blood pressure.
Flaa et al. (2008) conducted a cohort in Healthy (n=99). Arterial catecholamine concentrations during mental arithmetic was evaluated on Future systolic blood pressure (adjusted R(2)=0.651, p=<0.001). Arterial catecholamine concentrations during mental arithmetic explained 12.7% of the variation in future systolic blood pressure at 18-year follow-up (adjusted R2=0.651; P<0.001).