Acute left ventricular resynchronization of >=20% immediately after CRT implantation predicted a 93% response rate at 6 months, whereas <20% resynchronization resulted in no response.
Cohort (n=100)
Absolute Event Rate: 93% vs 0%
BACKGROUND: Recent studies have demonstrated that a positive response to cardiac resynchronization therapy (CRT) is related to the presence of preimplantation left ventricular (LV) dyssynchrony. The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown. METHODS AND RESULTS: One hundred consecutive patients scheduled for implantation of a CRT device were prospectively included if they met the following criteria: New York Heart Association class III to IV, LV ejection fraction 120 ms, and LV dyssynchrony (> or = 65 ms) on color-coded tissue Doppler imaging. Immediately after CRT implantation, LV dyssynchrony was reduced from 114+/-36 to 40+/-33 ms (P 10% reduction in LV end-systolic volume). Immediately after implantation, the responders to CRT demonstrated a significant reduction in LV dyssynchrony from 115+/-37 to 32+/-23 ms (P or = 20% responded to CRT. CONCLUSIONS: LV resynchronization after CRT is an acute phenomenon and predicts response to CRT at 6-month follow-up in patients with echocardiographic evidence of LV dyssynchrony at baseline.
Bleeker et al. (Wed,) conducted a cohort in Heart failure with LV dyssynchrony (n=100). Acute LV resynchronization >= 20% vs. Acute LV resynchronization < 20% was evaluated on Response to CRT (> 10% reduction in LV end-systolic volume) at 6 months. Acute left ventricular resynchronization of >=20% immediately after CRT implantation predicted a 93% response rate at 6 months, whereas <20% resynchronization resulted in no response.
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