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EBImage is free and open source, released under the LGPL license and available from the Bioconductor project (http://www.bioconductor.org/packages/release/bioc/html/EBImage.html).
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Grégoire Pau
Inserm
Florian Fuchs
Friedrich-Alexander-Universität Erlangen-Nürnberg
Oleg Sklyar
Bioinformatics
Heidelberg University
German Cancer Research Center
European Bioinformatics Institute
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Pau et al. (Tue,) studied this question.
synapsesocial.com/papers/69d7298e3f906f6a06bef80a — DOI: https://doi.org/10.1093/bioinformatics/btq046