Understanding the signaling pathways that regulate muscle protein synthesis and degradation may provide therapeutic targets for treating muscle wasting in metabolic and neuromuscular diseases.
Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutrients, and growth factors. Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases.
Marco Sandri (Sun,) conducted a review in Muscle atrophy and hypertrophy. Understanding the signaling pathways that regulate muscle protein synthesis and degradation may provide therapeutic targets for treating muscle wasting in metabolic and neuromuscular diseases.