Intravenous angiotensin II in conscious sheep produced a dose-dependent tachycardia via a central reduction in vagal tone, an effect normally antagonized by the baroreceptor reflex.
Intravenous infusions of angiotensin II were given to conscious sheep. During these infusions, the pressor action of angiotensin was antagonized by concomitant infusion of sodium nitroprusside. Under these conditions, angiotensin produced a dose-dependent tachycardia. This dose-dependent tachycardia was not affected by propranolol and therefore it was not due to an action of angiotensin on sympathoadrenal mechanisms. The dose-dependent tachycardia was reduced by atropine, and abolished by increases in systolic pressure. We conclude that iv infusions of angiotensin cause a central, dose-dependent reduction in vagal tone. This action is normally antagonized by the baroreceptor reflex response to the hypertensive action of angiotensin. Therefore, in those conditions in which endogenous angiotensin production is increased and blood pressure is not elevated (e.g., sodium deficiency and pregnancy), angiotensin may influence heart rate.
Lee et al. (Fri,) conducted a other in Conscious sheep. Intravenous angiotensin II was evaluated on Heart rate (tachycardia). Intravenous angiotensin II in conscious sheep produced a dose-dependent tachycardia via a central reduction in vagal tone, an effect normally antagonized by the baroreceptor reflex.