June 1, 2003
View Full PaperCognitive Activity and Risk of Alzheimer's Disease
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Abstract
Recent research suggests that frequent participation in cognitively stimulating activities may reduce risk of Alzheimer's disease in old age. We review epidemiological evidence of such an association. We then consider whether cognitive activity can account for the association between higher educational and occupational attainment and reduced risk of Alzheimer's disease. Finally, we discuss the behavioral and neurobiological mechanisms that may underlie the association between cognitive activity and risk of Alzheimer's disease.