A proposed mathematical technique can accurately estimate peak isovolumic developed pressure (Pmax) from a single ejecting beat in a canine model.
The relationship between peak isovolumic developed pressure (Pmax) and end-diastolic volume can indicate ventricular contractility. Therefore, we propose a practical method to estimate Pmax from the pressure curve of an ejecting contraction of left ventricle. For the estimation, we first considered the left ventricle a linear time varying hydromotive pressure source (HMP(t)) coupled in series with an internal impedance. To formulate the HMP(t) we Fourier analyzed isovolumic pressure curves obtained under various conditions in six dogs. Since the higher order harmonics were found to be very small, HMP(t) could be described simply as where Pd = end-diastolic pressure and w = 2/T in which T is duration of contraction. Finally, HMP(t) for ejecting contraction was estimated by fitting the equation to the isovolumic portions of the pressure curve of ejecting contractions. The estimated Pmax values correlated well with actually observed Pmax values (r = 0.951, N = 24). We conclude that the proposed technique can be used to estimate Pmax from a single ejecting beat.
Sunagawa et al. (Sun,) studied this question.