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Intratesticular tissue grafting might be the better choice for fertility restoration. Disrupting the stem cell niche might influence epigenetic patterns. Since the function of H4K5ac and H4K8ac in spermatogonia and spermatocytes still has to be explored, in-depth epigenetical analyses are warranted.
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Ellen Goossens
University College Ghent
T. Bilgec
Dorien Van Saen
Vrije Universiteit Brussel
Human Reproduction
Vrije Universiteit Brussel
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Goossens et al. (Thu,) studied this question.
synapsesocial.com/papers/69d81d4aa2a48916bbbef1f6 — DOI: https://doi.org/10.1093/humrep/der334