Does simvastatin and ezetimibe reduce the composite outcome of combined aortic-valve events and ischemic events in patients with aortic stenosis?
Patients with aortic stenosis
Simvastatin and ezetimibe
Composite outcome of combined aortic-valve events and ischemic eventscomposite
Intensive lipid lowering with simvastatin and ezetimibe does not prevent aortic-valve events in patients with aortic stenosis, although it reduces ischemic cardiovascular events.
Simvastatin and ezetimibe did not reduce the composite outcome of combined aortic-valve events and ischemic events in patients with aortic stenosis. Such therapy reduced the incidence of ischemic cardiovascular events but not events related to aortic-valve stenosis. (ClinicalTrials.gov number, NCT00092677.)
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Anne B. Rossebø
Terje R. Pedersen
Kurt Boman
New England Journal of Medicine
Lund University
University of Oslo
University of Bergen
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Rossebø et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69dd00fb8cc25b5e451334f4 — DOI: https://doi.org/10.1056/nejmoa0804602