Experimental data suggest that excitation-contraction coupling in heart muscle requires more complex single-mechanism models or dual-control models, rather than simple isolated mechanisms.
Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.
Lederer et al. (Sun,) conducted a other in Excitation-contraction coupling in heart cells. Experimental data suggest that excitation-contraction coupling in heart muscle requires more complex single-mechanism models or dual-control models, rather than simple isolated mechanisms.