The revised diagnostic cut-off of ejection fraction <55% for defining left ventricular systolic dysfunction lacks robust evidence and relies primarily on expert opinion.
The recent guidelines from the American Society of Echocardiography and European Society of Echocardiography have defined an abnormal ejection fraction (EF) of the left ventricle, as one that is 50%. The main limitation of this approach is how best to define risk. The cut-off points suggested for a single parameter can vary broadly for the risk of death, myocardial infarction, congestive heart failure and atrial fibrillation. Also, much of the literature applies to specific populations (eg, after myocardial infarction, the elderly) and not to overall cardiovascular risk.1 The recommended new cut-off EF value of 54% is based on expert opinion, interpreting data from the limited number of studies that have reported that an EF <54% is associated with moderate adverse outcomes.1 For example, Roman et al followed up 486 patients undergoing echocardiography to determine the prevalence of carotid atherosclerosis and to examine its relationship to LV hypertrophy.3 Two hundred and seventy-seven subjects were normotensive and 209 subjects had untreated hypertension, and all were asymptomatic with no overt manifestations of cerebrovascular disease. The investigators found that 392 patients were essentially without any evidence of carotid plaques and 366 patients had …
Mahadevan et al. (Thu,) conducted a editorial in Left ventricular systolic dysfunction. Revised ejection fraction cut-off (<55%) vs. Previous cut-off (40%) was evaluated. The revised diagnostic cut-off of ejection fraction <55% for defining left ventricular systolic dysfunction lacks robust evidence and relies primarily on expert opinion.