Is there a familial association and genetic predisposition in spontaneous coronary artery dissection (SCAD)?
This is the first series to identify a familial association in spontaneous coronary artery dissection (SCAD), suggesting it may be a heritable disorder.
To our knowledge, this series is the first to identify a familial association in SCAD suggesting a genetic predisposition. Recognition of SCAD as a heritable disorder has implications for at-risk family members and furthers our understanding of the pathogenesis of this complex disease. Whole-exome sequencing provides a unique opportunity to identify the molecular underpinnings of SCAD susceptibility.
Goel et al. (Mon,) studied this question.