Serum Activity Patterns of Glutamic Oxaloacetic Transaminase, Glutamic Pyruvic Transaminase and Lactic Dehydrogenase Following Graded Myocardial Infarction in Dogs

Following experimental myocardial infarction in the dog elevations of serum levels of glutamic-oxaloacetic transaminase (SGO-T), glutamic-pyruvic transaminase (SGP-T) and lactic dehydrogenase (SLD) were consistently noted in decreasing order. Evidence is presented that leakage into the serum from the damaged myocardium plays an important role in these elevations. This concept is supported by analyses of original tissue to blood enzyme concentration gradients, activities of homogenates of infarcts of varying ages, simultaneous measurements of coronary sinus and peripheral venous blood following infarction and contrasting results in man and the dog following infarction.