In patients with non-ischemic cardiomyopathy, the presence of myocardial scar detected by cardiac magnetic resonance was associated with a significantly higher risk of major adverse cardiac events (HR 3.40).
Meta-Analysis (n=2,747)
Does the presence of CMR-derived myocardial scar predict adverse cardiac and arrhythmic events in patients with non-ischemic cardiomyopathy?
CMR-derived myocardial scar is a strong predictor of adverse cardiac and arrhythmic events in patients with non-ischemic cardiomyopathy, highlighting its potential utility for sudden cardiac death risk stratification.
Effect estimate: HR 3.40 (95% CI 2.47-4.69)
p-value: p=<0.00001
In patients with non-ischemic cardiomyopathy (NICM), risk stratification for sudden cardiac death (SCD) and selection of patients who would benefit from prophylactic implantable cardioverter-defibrillators remains challenging. We aim to discuss the evidence of cardiac magnetic resonance (CMR)-derived myocardial scar for the prediction of adverse cardiovascular outcomes in NICM. From the 15 studies analyzed, with a total of 2747 patients, the average prevalence of myocardial scar was 41%. In patients with myocardial scar, the risk for adverse cardiac events was more than 3-fold higher, and risk for arrhythmic events 5-fold higher, as compared to patients without scar. Based on the available observational, single center studies, CMR scar assessment may be a promising new tool for SCD risk stratification, which merits further investigation.
Kim et al. (Thu,) conducted a meta-analysis in Non-Ischemic Cardiomyopathy (n=2,747). Presence of myocardial scar on cardiac magnetic resonance (CMR) vs. Absence of myocardial scar was evaluated on Major adverse cardiac events (MACE) (HR 3.40, 95% CI 2.47-4.69, p=<0.00001). In patients with non-ischemic cardiomyopathy, the presence of myocardial scar detected by cardiac magnetic resonance was associated with a significantly higher risk of major adverse cardiac events (HR 3.40).