Do tyrosine kinase inhibitors induce thyroid dysfunctions in patients undergoing cancer therapy?
Tyrosine kinase inhibitors are associated with thyroid dysfunctions, highlighting the need for routine thyroid monitoring in patients receiving these therapies.
Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy.
Illouz et al. (Fri,) studied this question.
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