Remarks on incomplete hypotheses for the control of cerebral circulation

✓ The role of focal ischemia and the altered circulation in a brain scar in relation to focal cerebral seizures has provided one of the continuing problems in the experimental approach to the mechanism of epilepsy. The brain of the epileptic patient as observed during craniotomy appears to show more vasomotor lability than the normal brain. This lability seems uninfluenced by sympathectomy or carotid artery sinus denervation. Epileptic lesions of all types show cytological evidence of ischemia. It seems likely that some undiscovered secret of cerebral circulation is the ultimate cause of epilepsy.