July 13, 2007
View Full PaperTiCl4-Catalyzed Indirect Anti-Markovnikov Hydration of Alkynes: Application to the Synthesis of Benzobfurans
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Abstract
An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzobfurans.