Frameshift Mutation: Determinants of Specificity

I NTRODUCTION 189 A REPERTOIRE OF FRAMESHIFT M ODELS 190 Additions or Deletions Mediated by a Single Misalignment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Mutations Mediated by Multiple Misalignments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 Frameshifts at Nicks: A Role for Misiigation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 OUTLOOK 206