Cell Biology of von Willebrand Factor

Key Points

• Review the cell biology, domain architecture, and biosynthetic pathway of von Willebrand factor.
• Synthesized molecular and cell biological findings on von Willebrand factor domain organization.
• Evaluated intracellular transport and maturation steps spanning the endoplasmic reticulum and Golgi compartments.
• Outlines the domain structure required for von Willebrand factor stability and multimerization.
• Details the sequential biosynthesis and modification of the protein within the endoplasmic reticulum and post-Golgi secretory pathways.